Exploring the world,
one molecule at a time.
Atomic models by: Fiona L Kearns, Mia A. Rosenfeld, Abigail C. Dommer, Lorenzo Casalino.
Image by: Mia A. Rosenfeld.
Recent Projects:
Conformational landscapes as functions of protein sequence.
The D614G mutation loosens a key region around communication networks in the SARS-CoV-2 spike contributing to easier to sample RBD-up conformational dynamics.
Conformational landscapes as functions of post-translational modifications.
Via torsional restrictions to the backbone, dense contact networks, and solvation effects, O-glycans imbue a physical “pseudo-structure” onto otherwise intrinsically disordered mucin backbones.
In our lab, we believe…
… the tenets of Equity, Diversity, and Inclusion are not just words but are the foundation upon which to build a working environment that fosters human-first innovation and discovery. Read our full “Lab Values” statement, and the philosophy behind them, at the link below.
